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Intracellular Mg(2+) is a voltage-dependent pore blocker of HCN channels

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are activated by membrane hyperpolarization that creates time-dependent, inward rectifying currents, gated by the movement of the intrinsic voltage sensor S4. However, inward rectification of the HCN currents is not only observed in...

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Detalhes bibliográficos
Main Authors: Vemana, Sriharsha, Pandey, Shilpi, Larsson, H. Peter
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518427/
https://ncbi.nlm.nih.gov/pubmed/18579800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00154.2008
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