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Topography of Diphtheria Toxin's T Domain in the Open Channel State

When diphtheria toxin encounters a low pH environment, the channel-forming T domain undergoes a poorly understood conformational change that allows for both its own membrane insertion and the translocation of the toxin's catalytic domain across the membrane. From the crystallographic structure...

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Autores principales: Senzel, Lisa, Gordon, Michael, Blaustein, Robert O., Oh, K. Joon, Collier, R. John, Finkelstein, Alan
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2000
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2233753/
https://ncbi.nlm.nih.gov/pubmed/10736310
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