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The EM structure of human DNA polymerase γ reveals a localized contact between the catalytic and accessory subunits

We used electron microscopy to examine the structure of human DNA pol γ, the heterotrimeric mtDNA replicase implicated in certain mitochondrial diseases and aging models. Separate analysis of negatively stained preparations of the catalytic subunit, pol γA, and of the holoenzyme including a dimeric...

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Detaylı Bibliyografya
Asıl Yazarlar: Yakubovskaya, Elena, Lukin, Mark, Chen, Zhixin, Berriman, John, Wall, Joseph S, Kobayashi, Ryuji, Kisker, Caroline, Bogenhagen, Daniel F
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2007
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2230839/
https://ncbi.nlm.nih.gov/pubmed/17762861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601843
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