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The EM structure of human DNA polymerase γ reveals a localized contact between the catalytic and accessory subunits
We used electron microscopy to examine the structure of human DNA pol γ, the heterotrimeric mtDNA replicase implicated in certain mitochondrial diseases and aging models. Separate analysis of negatively stained preparations of the catalytic subunit, pol γA, and of the holoenzyme including a dimeric...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2230839/ https://ncbi.nlm.nih.gov/pubmed/17762861 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601843 |
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