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The EM structure of human DNA polymerase γ reveals a localized contact between the catalytic and accessory subunits

We used electron microscopy to examine the structure of human DNA pol γ, the heterotrimeric mtDNA replicase implicated in certain mitochondrial diseases and aging models. Separate analysis of negatively stained preparations of the catalytic subunit, pol γA, and of the holoenzyme including a dimeric...

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Bibliografiske detaljer
Main Authors: Yakubovskaya, Elena, Lukin, Mark, Chen, Zhixin, Berriman, John, Wall, Joseph S, Kobayashi, Ryuji, Kisker, Caroline, Bogenhagen, Daniel F
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2230839/
https://ncbi.nlm.nih.gov/pubmed/17762861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601843
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