Sustained activation and tumor targeting of NKT cells using a CD1d–anti-HER2–scFv fusion protein induce antitumor effects in mice

Invariant NKT (iNKT) cells are potent activators of DCs, NK cells, and T cells, and their antitumor activity has been well demonstrated. A single injection of the high-affinity CD1d ligand α-galactosylceramide (αGalCer) leads to short-lived iNKT cell activation followed, however, by long-term anergy...

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Autori principali: Stirnemann, Kathrin, Romero, Jackeline F., Baldi, Lucia, Robert, Bruno, Cesson, Valérie, Besra, Gurdyal S., Zauderer, Maurice, Wurm, Florian, Corradin, Giampietro, Mach, Jean-Pierre, MacDonald, H. Robson, Donda, Alena
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2008
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2230658/
https://ncbi.nlm.nih.gov/pubmed/18259610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI33249
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