Developmental expression of wild-type and mutant presenilin-1 in hippocampal neurons from transgenic mice: evidence for novel species-specific properties of human presenilin-1.

Presenilins 1 (PS1) and 2 (PS2) are multispanning transmembrane proteins associated with familial Alzheimer disease (FAD). They are developmentally regulated, being expressed at highest levels during neuronal differentiation and are sustained at a lower level throughout life. We investigated the dis...

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Main Authors: Lévesque, L., Annaert, W., Craessaerts, K., Mathews, P. M., Seeger, M., Nixon, R. A., Van Leuven, F., Gandy, S., Westaway, D., St George-Hyslop, P., De Strooper, B., Fraser, P. E.
Formato: Artigo
Idioma:Inglês
Publicado: The Feinstein Institute for Medical Research 1999
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2230452/
https://ncbi.nlm.nih.gov/pubmed/10501657
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