High prion and PrPSc levels but delayed onset of disease in scrapie-inoculated mice heterozygous for a disrupted PrP gene.

BACKGROUND: It has been proposed that the prion, the infectious agent of transmissible spongiform encephalopathies, is PrPSc, a post-translationally modified form of the normal host protein PrPC. We showed previously that mice devoid of PrPC (Prn-p0/0) are completely resistant to scrapie. We now rep...

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Bibliographic Details
Main Authors: Büeler, H., Raeber, A., Sailer, A., Fischer, M., Aguzzi, A., Weissmann, C.
Format: Artigo
Language:Inglês
Published: The Feinstein Institute for Medical Research 1994
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2229922/
https://ncbi.nlm.nih.gov/pubmed/8790598
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