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PrP-dependent association of prions with splenic but not circulating lymphocytes of scrapie-infected mice.
An intact immune system, and particularly the presence of mature B lymphocytes, is crucial for mouse scrapie pathogenesis in the brain after peripheral exposure. Prions are accumulated in the lymphoreticular system (LRS), but the identity of the cells containing infectivity and their role in neuroin...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1999
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1171352/ https://ncbi.nlm.nih.gov/pubmed/10329617 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.10.2702 |
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