Selective 5HT(2A) and 5HT(6) Receptor Antagonists Promote Sleep in Rats

STUDY OBJECTIVES: Serotonin (5-HT) has long been implicated in the control of sleep and wakefulness. This study evaluated the hypnotic efficacy of the 5-HT(6) antagonist RO4368554 (RO) and the 5-HT(2A) receptor antagonist MDL100907 (MDL) relative to zolpidem. DESIGN: A randomized, repeated-measures...

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Detalhes bibliográficos
Main Authors: Morairty, Stephen R., Hedley, Linda, Flores, Judith, Martin, Renee, Kilduff, Thomas S.
Formato: Artigo
Idioma:Inglês
Publicado em: Associated Professional Sleep Societies, LLC 2008
Assuntos:
Serotonergic Mechanisms and Sleep
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2225549/
https://ncbi.nlm.nih.gov/pubmed/18220076
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