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Regulation of avoidant behaviors and pain by the anti-inflammatory tyrosine phosphatase SHP-1
The protein tyrosine phosphatase SHP-1 is a critical regulator of cytokine signaling and inflammation. Mice homozygous for a null allele at the SHP-1 locus have a phenotype of severe inflammation and are hyper-responsive to the TLR4 ligand LPS. TLR4 stimulation in the CNS has been linked to both neu...
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| Hlavní autoři: | , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2006
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2225530/ https://ncbi.nlm.nih.gov/pubmed/18250891 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1017/S1740925X07000476 |
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