Modulation of Macrophage Infiltration and Inflammatory Activity by the Phosphatase SHP-1 in Virus-Induced Demyelinating Disease

The protein tyrosine phosphatase SHP-1 is a crucial negative regulator of cytokine signaling and inflammatory gene expression, both in the immune system and in the central nervous system (CNS). Mice genetically lacking SHP-1 (me/me) display severe inflammatory demyelinating disease following inocula...

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Bibliographic Details
Main Authors: Christophi, George P., Hudson, Chad A., Panos, Michael, Gruber, Ross C., Massa, Paul T.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2009
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2612370/
https://ncbi.nlm.nih.gov/pubmed/18987138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01210-08
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