Macrophages of multiple sclerosis patients display deficient SHP-1 expression and enhanced inflammatory phenotype

Recent studies in mice have demonstrated that the protein tyrosine phosphatase SHP-1 is a crucial negative regulator of pro-inflammatory cytokine signaling, TLR signaling, and inflammatory gene expression. Furthermore, mice genetically lacking SHP-1 (me/me) display a profound susceptibility to infla...

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Detalhes bibliográficos
Main Authors: Christophi, George P., Panos, Michael, Hudson, Chad A., Christophi, Rebecca L., Gruber, Ross C., Mersich, Akos T., Blystone, Scott D., Jubelt, Burk, Massa, Paul T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2725397/
https://ncbi.nlm.nih.gov/pubmed/19398961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/labinvest.2009.32
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