Antiplasmodial Activity of [(Aryl)arylsulfanylmethyl]Pyridine

A series of [(aryl)arylsufanylmethyl]pyridines (AASMP) have been synthesized. These compounds inhibited hemozoin formation, formed complexes (K(D) = 12 to 20 μM) with free heme (ferriprotoporphyrin IX) at a pH close to the pH of the parasite food vacuole, and exhibited antimalarial activity in vitro...

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Detalhes bibliográficos
Main Authors: Kumar, Sanjay, Das, Sajal Kumar, Dey, Sumanta, Maity, Pallab, Guha, Mithu, Choubey, Vinay, Panda, Gautam, Bandyopadhyay, Uday
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2224759/
https://ncbi.nlm.nih.gov/pubmed/18025110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00898-07
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