Inhibition of Plasmodium falciparum Choline Kinase by Hexadecyltrimethylammonium Bromide: a Possible Antimalarial Mechanism

Choline kinase is the first enzyme in the Kennedy pathway (CDP-choline pathway) for the biosynthesis of the most essential phospholipid, phosphatidylcholine, in Plasmodium falciparum. In addition, choline kinase also plays a pivotal role in trapping essential polar head group choline inside the mala...

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Hlavní autoři: Choubey, Vinay, Maity, Pallab, Guha, Mithu, Kumar, Sanjay, Srivastava, Kumkum, Puri, Sunil Kumar, Bandyopadhyay, Uday
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2007
Témata:
Mechanisms of Action: Physiological Effects
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1797733/
https://ncbi.nlm.nih.gov/pubmed/17145794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00919-06
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