Mutations in the U5 Region Adjacent to the Primer Binding Site Affect tRNA Cleavage by Human Immunodeficiency Virus Type 1 Reverse Transcriptase In Vivo

In retroviruses, the first nucleotide added to the tRNA primer defines the end of the U5 region in the right long terminal repeat, and the subsequent removal of this tRNA primer by RNase H exactly defines the U5 end of the linear double-stranded DNA. In most retroviruses, the entire tRNA is removed...

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Bibliographische Detailangaben
Hauptverfasser: Oh, Jangsuk, McWilliams, Mary Jane, Julias, John G., Hughes, Stephen H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2008
Schlagworte:
Genome Replication and Regulation of Viral Gene Expression
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2224596/
https://ncbi.nlm.nih.gov/pubmed/17989171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02611-06
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