Attenuation of Recombinant Vesicular Stomatitis Virus-Human Immunodeficiency Virus Type 1 Vaccine Vectors by Gene Translocations and G Gene Truncation Reduces Neurovirulence and Enhances Immunogenicity in Mice

Recombinant vesicular stomatitis virus (rVSV) has shown great potential as a new viral vector for vaccination. However, the prototypic rVSV vector described previously was found to be insufficiently attenuated for clinical evaluation when assessed for neurovirulence in nonhuman primates. Here, we de...

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Xehetasun bibliografikoak
Egile Nagusiak: Cooper, David, Wright, Kevin J., Calderon, Priscilla C., Guo, Min, Nasar, Farooq, Johnson, J. Erik, Coleman, John W., Lee, Margaret, Kotash, Cheryl, Yurgelonis, Irene, Natuk, Robert J., Hendry, R. Michael, Udem, Stephen A., Clarke, David K.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology (ASM) 2008
Gaiak:
Vaccines and Antiviral Agents
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2224363/
https://ncbi.nlm.nih.gov/pubmed/17942549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01515-07
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