Attenuation of Recombinant Vesicular Stomatitis Virus-Human Immunodeficiency Virus Type 1 Vaccine Vectors by Gene Translocations and G Gene Truncation Reduces Neurovirulence and Enhances Immunogenicity in Mice

Recombinant vesicular stomatitis virus (rVSV) has shown great potential as a new viral vector for vaccination. However, the prototypic rVSV vector described previously was found to be insufficiently attenuated for clinical evaluation when assessed for neurovirulence in nonhuman primates. Here, we de...

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Detalhes bibliográficos
Main Authors: Cooper, David, Wright, Kevin J., Calderon, Priscilla C., Guo, Min, Nasar, Farooq, Johnson, J. Erik, Coleman, John W., Lee, Margaret, Kotash, Cheryl, Yurgelonis, Irene, Natuk, Robert J., Hendry, R. Michael, Udem, Stephen A., Clarke, David K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2224363/
https://ncbi.nlm.nih.gov/pubmed/17942549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01515-07
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