Recombinant Vesicular Stomatitis Virus Vectors Expressing Herpes Simplex Virus Type 2 gD Elicit Robust CD4(+) Th1 Immune Responses and Are Protective in Mouse and Guinea Pig Models of Vaginal Challenge

Recombinant vesicular stomatitis virus (rVSV) vectors offer an attractive approach for the induction of robust cellular and humoral immune responses directed against human pathogen target antigens. We evaluated rVSV vectors expressing full-length glycoprotein D (gD) from herpes simplex virus type 2...

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Detalhes bibliográficos
Main Authors: Natuk, Robert J., Cooper, David, Guo, Min, Calderon, Priscilla, Wright, Kevin J., Nasar, Farooq, Witko, Susan, Pawlyk, Diane, Lee, Margaret, DeStefano, Joanne, Tummolo, Donna, Abramovitz, Aaron S., Gangolli, Seema, Kalyan, Narender, Clarke, David K., Hendry, R. Michael, Eldridge, John H., Udem, Stephen A., Kowalski, Jacek
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1472036/
https://ncbi.nlm.nih.gov/pubmed/16611905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.9.4447-4457.2006
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