Recombinant Vesicular Stomatitis Virus Vectors Expressing Herpes Simplex Virus Type 2 gD Elicit Robust CD4(+) Th1 Immune Responses and Are Protective in Mouse and Guinea Pig Models of Vaginal Challenge

Recombinant vesicular stomatitis virus (rVSV) vectors offer an attractive approach for the induction of robust cellular and humoral immune responses directed against human pathogen target antigens. We evaluated rVSV vectors expressing full-length glycoprotein D (gD) from herpes simplex virus type 2...

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Main Authors: Natuk, Robert J., Cooper, David, Guo, Min, Calderon, Priscilla, Wright, Kevin J., Nasar, Farooq, Witko, Susan, Pawlyk, Diane, Lee, Margaret, DeStefano, Joanne, Tummolo, Donna, Abramovitz, Aaron S., Gangolli, Seema, Kalyan, Narender, Clarke, David K., Hendry, R. Michael, Eldridge, John H., Udem, Stephen A., Kowalski, Jacek
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology 2006
נושאים:
Vaccines and Antiviral Agents
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC1472036/
https://ncbi.nlm.nih.gov/pubmed/16611905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.9.4447-4457.2006
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