Madurahydroxylactone Derivatives as Dual Inhibitors of Human Immunodeficiency Virus Type 1 Integrase and RNase H

A series of 29 madurahydroxylactone derivatives was evaluated for dual inhibition of human immunodeficiency virus type 1 (HIV-1) integrase and RNase H. While most of the compounds exhibited similar potencies for both enzymes, two of the derivatives showed 10- to 100-fold-higher selectivity for each...

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Hlavní autoři: Marchand, Christophe, Beutler, John A., Wamiru, Antony, Budihas, Scott, Möllmann, Ute, Heinisch, Lothar, Mellors, John W., Le Grice, Stuart F., Pommier, Yves
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2008
Témata:
Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2223906/
https://ncbi.nlm.nih.gov/pubmed/17967911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00883-07
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