Azido-Containing Diketo Acid Derivatives Inhibit Human Immunodeficiency Virus Type 1 Integrase In Vivo and Influence the Frequency of Deletions at Two-Long-Terminal-Repeat-Circle Junctions

We previously found that azido-containing β-diketo acid derivatives (DKAs) are potent inhibitors of human immunodeficiency virus type 1 (HIV-1) integrase (IN) (X. Zhang et al., Bioorg. Med. Chem. Lett., 13:1215-1219, 2003). To characterize the intracellular mechanisms of action of DKAs, we analyzed...

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Main Authors: Svarovskaia, Evguenia S., Barr, Rebekah, Zhang, Xuechun, Pais, Godwin C. G., Marchand, Christophe, Pommier, Yves, Burke, Terrence R., Pathak, Vinay K.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2004
Assuntos:
Vaccines and Antiviral Agents
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC371038/
https://ncbi.nlm.nih.gov/pubmed/15016842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.7.3210-3222.2004
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