Structure-based design of Taq DNA polymerases with improved properties of dideoxynucleotide incorporation
The Taq DNA polymerase is the most commonly used enzyme in DNA sequencing. However, all versions of Taq polymerase are deficient in two respects: (i) these enzymes incorporate each of the four dideoxynucleoside 5′ triphosphates (ddNTPs) at widely different rates during sequencing (ddGTP, for example...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1999
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22236/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10449720/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.17.9491 |
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