p27(kip1) Deficiency Impairs G(2)/M Arrest in Response to DNA Damage, Leading to an Increase in Genetic Instability

p27(kip1) is a cyclin-dependent kinase inhibitor and a tumor suppressor. In some tumors, p27 suppresses tumor growth by inhibition of cell proliferation. However, this is not universally observed, implying additional mechanisms of tumor suppression by p27. p27-deficient mice are particularly suscept...

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Detalhes bibliográficos
Main Authors: Payne, Shannon R., Zhang, Shulin, Tsuchiya, Karen, Moser, Russell, Gurley, Kay E., Longton, Gary, deBoer, Johan, Kemp, Christopher J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2223298/
https://ncbi.nlm.nih.gov/pubmed/17954563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01536-07
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