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Serine 15 Phosphorylation of p53 Directs Its Interaction with B56γ and the Tumor Suppressor Activity of B56γ-Specific Protein Phosphatase 2A

Earlier studies have demonstrated a functional link between B56γ-specific protein phosphatase 2A (B56γ-PP2A) and p53 tumor suppressor activity. Upon DNA damage, a complex including B56γ-PP2A and p53 is formed which leads to Thr55 dephosphorylation of p53, induction of the p53 transcriptional target...

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Bibliografiset tiedot
Päätekijät: Shouse, Geoffrey P., Cai, Xin, Liu, Xuan
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology (ASM) 2008
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2223295/
https://ncbi.nlm.nih.gov/pubmed/17967874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00983-07
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