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Characterization of B56γ tumor-associated mutations reveals mechanisms for inactivation of B56γ-PP2A
A subset of the hetero-trimeric PP2A serine/threonine phosphatases that contain B56, and in particular B56γ, can function as tumor suppressors. In response to DNA damage, the B56γ subunit complexes with the PP2A AC core (B56γ–PP2A) and binds p53. This event promotes PP2A-mediated dephosphorylation o...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3778137/ https://ncbi.nlm.nih.gov/pubmed/23723076 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-12-0633 |
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