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Rapamycin inhibits differentiation of Th17 cells and promotes generation of FoxP3+ T regulatory cells
Reciprocal differentiation of immunosuppressive CD4(+)CD25(+)FoxP3(+) T regulatory cells (Tregs) and proinflammatory IL-17-producing cells (Th17) from naïve CD4 cells is contingent upon the cytokine environment. Using MACS-purified CD4 cells, we found that rapamycin and cyclosporine A (CsA) potently...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2007
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2223142/ https://ncbi.nlm.nih.gov/pubmed/17996694 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.intimp.2007.08.027 |
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