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Vaccinia virus N1L protein resembles a B cell lymphoma-2 (Bcl-2) family protein

Poxviruses encode immuno-modulatory proteins capable of subverting host defenses. The poxvirus vaccinia expresses a small 14-kDa protein, N1L, that is critical for virulence. We report the crystal structure of N1L, which reveals an unexpected but striking resemblance to host apoptotic regulators of...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Aoyagi, Mika, Zhai, Dayong, Jin, Chaofang, Aleshin, Alexander E., Stec, Boguslaw, Reed, John C., Liddington, Robert C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2007
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2222835/
https://ncbi.nlm.nih.gov/pubmed/17123957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.062454707
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