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Critical contribution of VH–VL interaction to reshaping of an antibody: The case of humanization of anti-lysozyme antibody, HyHEL-10

To clarify the effects of humanizing a murine antibody on its specificity and affinity for its target, we examined the interaction between hen egg white lysozyme (HEL) and its antibody, HyHEL-10 variable domain fragment (Fv). We selected a human antibody framework sequence with high homology, grafte...

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Sonraí Bibleagrafaíochta
Main Authors: Nakanishi, Takeshi, Tsumoto, Kouhei, Yokota, Akiko, Kondo, Hidemasa, Kumagai, Izumi
Formáid: Artigo
Teanga:Inglês
Foilsithe: Cold Spring Harbor Laboratory Press 2008
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2222731/
https://ncbi.nlm.nih.gov/pubmed/18227432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.073156708
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