Загрузка...

Critical contribution of VH–VL interaction to reshaping of an antibody: The case of humanization of anti-lysozyme antibody, HyHEL-10

To clarify the effects of humanizing a murine antibody on its specificity and affinity for its target, we examined the interaction between hen egg white lysozyme (HEL) and its antibody, HyHEL-10 variable domain fragment (Fv). We selected a human antibody framework sequence with high homology, grafte...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Nakanishi, Takeshi, Tsumoto, Kouhei, Yokota, Akiko, Kondo, Hidemasa, Kumagai, Izumi
Формат: Artigo
Язык:Inglês
Опубликовано: Cold Spring Harbor Laboratory Press 2008
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2222731/
https://ncbi.nlm.nih.gov/pubmed/18227432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.073156708
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!