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Critical contribution of VH–VL interaction to reshaping of an antibody: The case of humanization of anti-lysozyme antibody, HyHEL-10
To clarify the effects of humanizing a murine antibody on its specificity and affinity for its target, we examined the interaction between hen egg white lysozyme (HEL) and its antibody, HyHEL-10 variable domain fragment (Fv). We selected a human antibody framework sequence with high homology, grafte...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Cold Spring Harbor Laboratory Press
2008
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2222731/ https://ncbi.nlm.nih.gov/pubmed/18227432 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.073156708 |
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