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Proteomic analysis of the amyloid precursor protein fragment C99: expression in yeast

The accumulation and aggregation of fragments of amyloid precursor protein (APP) are central to the development of Alzheimer's disease. The production of the small fragment C99 is thought to form the rate-limiting step in the APP processing pathway, which can lead to the production of the toxic...

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Detalhes bibliográficos
Main Authors: Sparvero, Louis J., Patz, Sarah, Brodsky, Jeffrey L., Coughlan, Christina M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2220045/
https://ncbi.nlm.nih.gov/pubmed/17869211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ab.2007.07.033
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