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Mechanism of cytotoxicity mediated by the C31 fragment of the Amyloid Precursor Protein
The cytoplasmic tail of the amyloid precursor protein (APP) contains two putatively cytotoxic peptides, Jcasp and C31, derived by caspase cleavage of APP. Jcasp is a fragment starting from the ε-secretase site to position 664, while C31 is a fragment from position 665 to the C-terminus. Our studies...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2838490/ https://ncbi.nlm.nih.gov/pubmed/19679105 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2009.08.042 |
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