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Protons Block BK Channels by Competitive Inhibition with K(+) and Contribute to the Limits of Unitary Currents at High Voltages
Proton block of unitary currents through BK channels was investigated with single-channel recording. Increasing intracellular proton concentration decreased unitary current amplitudes with an apparent pKa of 5.1 without discrete blocking events, indicating fast proton block. Unitary currents recorde...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
The Rockefeller University Press
2004
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2217450/ https://ncbi.nlm.nih.gov/pubmed/14981139 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200308951 |
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