Ring of Negative Charge in BK Channels Facilitates Block by Intracellular Mg(2+) and Polyamines through Electrostatics

Eitemau Tebyg

• A ring of eight conserved negatively charged amino acids doubles the conductance of BK channels and prevents inward rectification
  gan: Brelidze, Tinatin I., et al.
  Cyhoeddwyd: (2003)
• Protons Block BK Channels by Competitive Inhibition with K(+) and Contribute to the Limits of Unitary Currents at High Voltages
  gan: Brelidze, Tinatin I., et al.
  Cyhoeddwyd: (2004)
• Probing the Geometry of the Inner Vestibule of BK Channels with Sugars
  gan: Brelidze, Tinatin I., et al.
  Cyhoeddwyd: (2005)
• β1 subunits facilitate gating of BK channels by acting through the Ca(2)(+), but not the Mg(2)(+), activating mechanisms
  gan: Qian, Xiang, et al.
  Cyhoeddwyd: (2003)
• Stepwise contribution of each subunit to the cooperative activation of BK channels by Ca(2+)
  gan: Niu, Xiaowei, et al.
  Cyhoeddwyd: (2002)