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p200 ARF–GEP1: A Golgi-localized guanine nucleotide exchange protein whose Sec7 domain is targeted by the drug brefeldin A

The drug brefeldin A (BFA) disrupts protein traffic and Golgi morphology by blocking activation of ADP ribosylation factors (ARFs) through an unknown mechanism. Here, we investigated the cellular localization and BFA sensitivity of human p200 ARF-GEP1 (p200), a ubiquitously expressed guanine nucleot...

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Main Authors: Mansour, Sam J., Skaug, Jennifer, Zhao, Xin-Hua, Giordano, Jennifer, Scherer, Stephen W., Melançon, Paul
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 1999
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Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC22171/
https://ncbi.nlm.nih.gov/pubmed/10393931
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