Natural HLA Class I Polymorphism Controls the Pathway of Antigen Presentation and Susceptibility to Viral Evasion

HLA class I polymorphism creates diversity in epitope specificity and T cell repertoire. We show that HLA polymorphism also controls the choice of Ag presentation pathway. A single amino acid polymorphism that distinguishes HLA-B*4402 (Asp116) from B*4405 (Tyr116) permits B*4405 to constitutively ac...

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Main Authors: Zernich, Danielle, Purcell, Anthony W., Macdonald, Whitney A., Kjer-Nielsen, Lars, Ely, Lauren K., Laham, Nihay, Crockford, Tanya, Mifsud, Nicole A., Bharadwaj, Mandvi, Chang, Linus, Tait, Brian D., Holdsworth, Rhonda, Brooks, Andrew G., Bottomley, Stephen P., Beddoe, Travis, Peh, Chen Au, Rossjohn, Jamie, McCluskey, James
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2004
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2213310/
https://ncbi.nlm.nih.gov/pubmed/15226359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20031680
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