A Naturally Selected Dimorphism within the HLA-B44 Supertype Alters Class I Structure, Peptide Repertoire, and T Cell Recognition

HLA-B*4402 and B*4403 are naturally occurring MHC class I alleles that are both found at a high frequency in all human populations, and yet they only differ by one residue on the α2 helix (B*4402 Asp156→B*4403 Leu156). CTLs discriminate between HLA-B*4402 and B*4403, and these allotypes stimulate st...

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Main Authors: Macdonald, Whitney A., Purcell, Anthony W., Mifsud, Nicole A., Ely, Lauren K., Williams, David S., Chang, Linus, Gorman, Jeffrey J., Clements, Craig S., Kjer-Nielsen, Lars, Koelle, David M., Burrows, Scott R., Tait, Brian D., Holdsworth, Rhonda, Brooks, Andrew G., Lovrecz, George O., Lu, Louis, Rossjohn, Jamie, McCluskey, James
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2003
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2194191/
https://ncbi.nlm.nih.gov/pubmed/12939341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20030066
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