Bruton's Tyrosine Kinase Is Essential for Human B Cell Tolerance

Most polyreactive and antinuclear antibodies are removed from the human antibody repertoire during B cell development. To elucidate how B cell receptor (BCR) signaling may regulate human B cell tolerance, we tested the specificity of recombinant antibodies from single peripheral B cells isolated fro...

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Hlavní autoři: Ng, Yen-Shing, Wardemann, Hedda, Chelnis, James, Cunningham-Rundles, Charlotte, Meffre, Eric
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2004
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2213290/
https://ncbi.nlm.nih.gov/pubmed/15466623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20040920
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