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CD40 ligand and MHC class II expression are essential for human peripheral B cell tolerance
Hyper-IgM (HIGM) syndromes are primary immunodeficiencies characterized by defects of class switch recombination and somatic hypermutation. HIGM patients who carry mutations in the CD40-ligand (CD40L) gene expressed by CD4(+) T cells suffer from recurrent infections and often develop autoimmune diso...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The Rockefeller University Press
2007
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2118633/ https://ncbi.nlm.nih.gov/pubmed/17562816 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20062287 |
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