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Bruton’s tyrosine kinase is not essential for B cell survival beyond early developmental stages
Bruton’s tyrosine kinase (Btk) is a crucial regulator of B cell signaling and is a therapeutic target for lymphoma and autoimmune disease. BTK-deficient patients suffer from humoral immunodeficiency, as their B cells fail to progress beyond the bone marrow. However, the role of Btk in fully develope...
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| Veröffentlicht in: | J Immunol |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6177684/ https://ncbi.nlm.nih.gov/pubmed/29483358 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1701489 |
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