Bruton’s tyrosine kinase deficiency inhibits autoimmune arthritis but fails to block immune complex-mediated inflammatory arthritis

OBJECTIVE: Bruton’s Tyrosine Kinase (BTK) is a B cell signaling protein that also contributes to innate immunity. BTK-inhibitors prevent autoimmune arthritis, but have off-target effects, and the mechanisms of protection remain unknown. These studies used genetic deletion to investigate the role of...

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Detalhes bibliográficos
Publicado no:Arthritis Rheumatol
Main Authors: Nyhoff, Lindsay E., Barron, Bridgette, Johnson, Elizabeth M., Bonami, Rachel H., Maseda, Damian, Fensterheim, Benjamin A., Han, Wei, Blackwell, Timothy S., Crofford, Leslie J., Kendall, Peggy L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5668904/
https://ncbi.nlm.nih.gov/pubmed/26945549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.39657
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