Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-α induction

Toll-like receptors (TLRs) recognize microbial pathogens and trigger innate immune responses. Among TLR family members, TLR7, TLR8, and TLR9 induce interferon (IFN)-α in plasmacytoid dendritic cells (pDCs). This induction requires the formation of a complex consisting of the adaptor MyD88, tumor nec...

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Hauptverfasser: Uematsu, Satoshi, Sato, Shintaro, Yamamoto, Masahiro, Hirotani, Tomonori, Kato, Hiroki, Takeshita, Fumihiko, Matsuda, Michiyuki, Coban, Cevayir, Ishii, Ken J., Kawai, Taro, Takeuchi, Osamu, Akira, Shizuo
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2005
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2213113/
https://ncbi.nlm.nih.gov/pubmed/15767370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20042372
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