DAP12 (KARAP) amplifies inflammation and increases mortality from endotoxemia and septic peritonitis

DAP12 (KARAP) is a transmembrane signaling adaptor for a family of innate immunoreceptors that have been shown to activate granulocytes and monocytes/macrophages, amplifying production of inflammatory cytokines. Contrasting with these data, recent studies suggest that DAP12 signaling has an inhibito...

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Dettagli Bibliografici
Autori principali: Turnbull, Isaiah R., McDunn, Jonathan E., Takai, Toshiyuki, Townsend, R. Reid, Cobb, J. Perren, Colonna, Marco
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2005
Soggetti:
Brief Definitive Report
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2213081/
https://ncbi.nlm.nih.gov/pubmed/16061725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20050986
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