Defective thrombus formation in mice lacking coagulation factor XII

Blood coagulation is thought to be initiated by plasma protease factor VIIa in complex with the membrane protein tissue factor. In contrast, coagulation factor XII (FXII)–mediated fibrin formation is not believed to play an important role for coagulation in vivo. We used FXII-deficient mice to study...

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Main Authors: Renné, Thomas, Pozgajová, Miroslava, Grüner, Sabine, Schuh, Kai, Pauer, Hans-Ulrich, Burfeind, Peter, Gailani, David, Nieswandt, Bernhard
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2005
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2213000/
https://ncbi.nlm.nih.gov/pubmed/16009717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20050664
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