Targeting coagulation factor XII provides protection from pathological thrombosis in cerebral ischemia without interfering with hemostasis

Formation of fibrin is critical for limiting blood loss at a site of blood vessel injury (hemostasis), but may also contribute to vascular thrombosis. Hereditary deficiency of factor XII (FXII), the protease that triggers the intrinsic pathway of coagulation in vitro, is not associated with spontane...

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Dettagli Bibliografici
Autori principali: Kleinschnitz, Christoph, Stoll, Guido, Bendszus, Martin, Schuh, Kai, Pauer, Hans-Ulrich, Burfeind, Peter, Renné, Christoph, Gailani, David, Nieswandt, Bernhard, Renné, Thomas
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2006
Soggetti:
Brief Definitive Reports
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118228/
https://ncbi.nlm.nih.gov/pubmed/16533887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20052458
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