Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus

Systemic autoimmune disease in humans and mice is characterized by loss of immunologic tolerance to a restricted set of self-nuclear antigens. Autoantigens, such as double-stranded (ds) DNA and the RNA-containing Smith antigen (Sm), may be selectively targeted in systemic lupus erythematosus because...

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Main Authors: Christensen, Sean R., Kashgarian, Michael, Alexopoulou, Lena, Flavell, Richard A., Akira, Shizuo, Shlomchik, Mark J.
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2005
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212997/
https://ncbi.nlm.nih.gov/pubmed/16027240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20050338
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