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The very 5′ end and the constant region of Ig genes are spared from somatic mutation because AID does not access these regions
Somatic hypermutation (SHM) is restricted to VDJ regions and their adjacent flanks in immunoglobulin (Ig) genes, whereas constant regions are spared. Mutations occur after about 100 nucleotides downstream of the promoter and extend to 1–2 kb. We have asked why the very 5′ and most of the 3′ region o...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The Rockefeller University Press
2005
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2212980/ https://ncbi.nlm.nih.gov/pubmed/16301749 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20051604 |
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