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The pattern of somatic hypermutation of Ig genes is altered when p53 is inactivated
Mice with a deletion of the p53 gene have normal antibody titers against sheep red blood cells and normal switching to all Ig isotypes. In older mice (11 and 16 weeks old) the somatic hypermutation (SHM) frequencies are progressively reduced. In young mice (8 weeks old) with p53 deletion, the SHM fr...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2010
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3038623/ https://ncbi.nlm.nih.gov/pubmed/20691478 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2010.05.291 |
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