Recruitment of latent pools of high-avidity CD8(+) T cells to the antitumor immune response

A major barrier to successful antitumor vaccination is tolerance of high-avidity T cells specific to tumor antigens. In keeping with this notion, HER-2/neu (neu)-targeted vaccines, which raise strong CD8(+) T cell responses to a dominant peptide (RNEU(420-429)) in WT FVB/N mice and protect them from...

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Detalhes bibliográficos
Main Authors: Ercolini, Anne M., Ladle, Brian H., Manning, Elizabeth A., Pfannenstiel, Lukas W., Armstrong, Todd D., Machiels, Jean-Pascal H., Bieler, Joan G., Emens, Leisha A., Reilly, R. Todd, Jaffee, Elizabeth M.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2005
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212915/
https://ncbi.nlm.nih.gov/pubmed/15883172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20042167
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