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Apoptosis-regulated low avidity cancer-specific CD8(+) T cells can be rescued to eliminate HER-2/neu-expressing tumors by costimulatory agonists in tolerized mice
A major barrier of vaccines as cancer treatment is their failure to activate and maintain a complete cancer-specific CD8(+) effector T cell repertoire. Low avidity T cells are more likely to escape clonal deletion in the thymus when compared to higher avidity T cells, and therefore comprise the majo...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4001125/ https://ncbi.nlm.nih.gov/pubmed/24764578 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-13-0145 |
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