Antibody association with HER-2/neu–targeted vaccine enhances CD8(+) T cell responses in mice through Fc-mediated activation of DCs

The pathogenic nature of cancer is attributed, at least in part, to the ability of tumors cells to induce systemic and local mechanisms of immune tolerance. However, we previously reported that tumor-free survival in up to 100% of tolerized HER-2/neu transgenic mice can be achieved by administration...

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Hauptverfasser: Kim, Peter S., Armstrong, Todd D., Song, Hong, Wolpoe, Matthew E., Weiss, Vivian, Manning, Elizabeth A., Huang, Lan Qing, Murata, Satoshi, Sgouros, George, Emens, Leisha A., Reilly, R. Todd, Jaffee, Elizabeth M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2008
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2289797/
https://ncbi.nlm.nih.gov/pubmed/18398507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI34333
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